Seizure Recurrence after Medication Withdrawal

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Seizure recurrence and risk factors after withdrawal of chronic antiepileptic therapy in children

The aim of this study was to identify the risk factors for seizure recurrence after withdrawal of chronic antiepileptic therapy in 226 children: 136 with partial epilepsies and 90 with generalized epilepsies. The influence on prognosis of the different variables was assessed retrospectively with univariate and multivariate analysis. With a mean observation period of 5.85+/-3.87 years, seizure r...

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Low risk of seizure recurrence after early withdrawal of antiepileptic treatment in the neonatal period.

The risk of seizure recurrence within the first year of life was evaluated in infants with neonatal seizures diagnosed with a combination of clinical signs, amplitude-integrated electroencephalogram (EEG) monitoring, and standard EEG. Fifty eight of 283 (4.5%) neonates in tertiary level neonatal intensive care had seizures. The mortality in the infants with neonatal seizures was 36.2%. In 31 su...

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Risk of recurrence after a first unprovoked seizure.

The risk of recurrence after a first unprovoked seizure has been examined in numerous observational studies and two large, high-quality randomized trials. Overall, in untreated individuals, 40-50% can expect a recurrence within 2 years of the initial seizure. Treatment may reduce this risk by as much as half. Those at the greatest risk of recurrence have either an abnormal EEG or an identifiabl...

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Seizure recurrence 29 years after hemispherectomy for Sturge Weber syndrome.

associated with venous angiomatosis of the leptomeninges and ipsilateral, cutaneous facial port-wine stain (facial angiomatosis). Seizures are seen in more than 80% of cases, cognitive impairment in 50% and frequently glaucoma.1-2 Seizures are the result of leptomeningeal angioma and underlying calcifications. These abnormalities are usually considered to be limited to one hemisphere. Frequentl...

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Risk of recurrence after drug withdrawal in childhood epilepsy

OBJECTIVES After a reasonable seizure-free period, discontinuation of antiepileptic drugs (AED) is usually decided in epileptic patients despite the risk of seizure recurrence. In children, risk of recurrence after discontinuation of AED is generally 20-40%; however, there is still no general agreement on the criteria to predict safe discontinuation. This study was designed to determine the ris...

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ژورنال

عنوان ژورنال: Pediatric Neurology Briefs

سال: 1988

ISSN: 2166-6482,1043-3155

DOI: 10.15844/pedneurbriefs-2-7-11